Table 7

Twenty leading causes of DALYs, by sex, US 1996
	Males

	Cause list	DALY	% total
	Total DALY	17,860,393
1	Ischaemic heart disease	1,958,184	11.0%
2	Motor vehicle accidents	933,798	5.2%
3	Lung trachea or bronchial cancer	812,804	4.6%
4	HIV	763,816	4.3%
5	Alcohol use	731,890	4.1%
6	Cerebrovascular Disease	673,928	3.8%
7	COPD	641,701	3.6%
8	Homicide and Violence	567,717	3.2%
9	Self-inflicted	541,399	3.0%
10	Unipolar major depression	469,929	2.6%
11	Diabetes mellitus	442,051	2.5%
12	Osteoarthritis	434,856	2.4%
13	Drug use	411,780	2.3%
14	Congenital Abnomalities	410,388	2.3%
15	Dementia and other degenerative and hereditary CNS disorders	382,392	2.1%
16	Asthma	303,088	1.7%
17	Cirrhosis of the liver	280,632	1.6%
18	Conditions arising during the perinatal period	273,577	1.5%
19	Cancer colon or rectum	249,462	1.4%
20	Prostate cancer	238,889	1.3%

	sub-total	11,522,281	64.5%


	Females

	Cause list	DALY	% total
	Total DALY	15,229,819
1	Ischaemic heart disease	1,176,548	7.7%
2	Unipolar major depression	900,356	5.9%
3	Cerebrovascular Disease	836,359	5.5%
4	COPD	611,790	4.0%
5	Lung trachea or bronchial cancer	549,908	3.6%
6	Breast cancer	514,786	3.4%
7	Osteoarthritis	507,826	3.3%
8	Dementia and other degenerative and hereditary CNS disorders	506,849	3.3%
9	Diabetes mellitus	504,240	3.3%
10	Motor vehicle accidents	459,480	3.0%
11	Alcohol use	409,303	2.7%
12	Asthma	362,015	2.4%
13	Congenital Abnomalities	351,563	2.3%
14	Cancer colon or rectum	234,469	1.5%
15	Conditions arising during the perinatal period	220,382	1.4%
16	Lower respiratory infections	195,448	1.3%
17	PTSD	193,533	1.3%
18	HIV	192,602	1.3%
19	Panic disorder	182,218	1.2%
20	Bipolar disorder	165,236	1.1%

Michaud et al. Population Health Metrics 2006 4:11 doi:10.1186/1478-7954-4-11